Publicado por: sosortomolecular | 13 de Julho de 2009


A lactulose é um açúcar não absorvível pelo intestino delgado humano. Assim, ela chega ao cólon praticamente inalterada. Nesse local, é fermentada pelas bactérias sacarolíticas, originando principalmente o ácido láctico.
  Por ter a capacidade de acidificar o intestino, aumenta a pressão osmótica e o afluxo de líquidos, aumentando o volume das fezes e favorecendo o trânsito intestinal.
  A lactulose é, o nutriente ideal das bifidobactérias e dos lactobacilos, como um prebiótico ajuda a estabilizar e a recuperar a flora intestinal fisiológica.
  Na natureza, os prebióticos se encontram nos vegetais, como o alho, o aspargo, a cebola, o tomate, a alcachofra, a banana, a cevada, a aveia, o trigo e o mel.
  No crescimento bacteriano que ocorre no interior do intestino delgado, a lactulose é fermentada antes de chegar ao cólon e produz um pico de hidrogênio.
  Um estudo publicado relacionou os níveis de endotoxina bacteriana com pacientes que tem fibromialgia. As bactérias Gram-negativas tem uma endotoxina, um liposacarídeo (LPS) que tem uma grande capacidade de virulencia, que tem o efeito de amplificar as reações inflamatórias o que lhes confere a propriedade de patogenicidade. Os autores levantaram a hipótese de que os níveis de endotoxina bacteriana seriam maiores nos pacientes com fibromialgia, e como esta é uma substância que produz hiperalgesia, ela estaria envolvida na patogênese da fibromialgia.
 As bactérias anaeróbias ao fermentarem o carboidrato que não foi digerido produzem gases como o hidrogênio que chega na corrente sangüínea, e ao ser eliminado pela respiração pode ser medido pelo teste respiratório da lactulose. Se existe um excesso de bactérias, os níveis de hidrogênio detectados serão maiores e a produção de hidrogênio foi significativamente maior nos pacientes com fibromialgia.


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